Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Hedgehog (Hh) - RU-SKI 43 hydrochloride

RU-SKI 43 hydrochloride

CAS No. ——

RU-SKI 43 hydrochloride( RU-SKI43 hydrochloride )

Catalog No. M16978 CAS No. ——

A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    RU-SKI 43 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
  • Description
    A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM; specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src; reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RU-SKI43 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog (Hh)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    423.0117
  • Molecular Formula
    C22H31ClN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 51 mg/mL
  • SMILES
    ——
  • Chemical Name
    Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Petrova E, et al. Nat Chem Biol. 2013 Apr;9(4):247-9. 2. Petrova E, et al. Oncogene. 2015 Jan 8;34(2):263-8. 3. Matevossian A, et al. Mol Cancer. 2015 Apr 1;14:72.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • SAG 21k

    SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.

  • BRD9526

    BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM.

  • Robotnikinin

    Robotnikinin is asmall molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines.

Sign In Join Free